• CBD shows little affinity for CB1 and 2 receptors. Instead it modulates several non-cannabinoid receptors and ion channels.

• CBD delays the uptake of endogenous neurotransmitters like Anandamide and Adenosine

• High doses activate the 5-HT1A receptor to which serotonin binds.

• Binds to Vanilloid, or TRPV1 receptors, which influence the perception of pain, especially neural, and heat.

• Overactive GRP55 receptors are associated with IBS and osteoporosis. CBD is an antagonist of  GRP55, which means that it prevents the hormones from binding to receptor sites slowing the inflammation associated with IBS. This same mechanism encourages bones to shed old, brittle tissue so that it can be replaced with new healthy bones.

• The reduction and blocking of GPR55 activity, as induced by CBD, has been shown to exhibit anti-tumour effects in certain types of cancer including colorectal, breast, pancreatic, and brain.

• CBD activates Peroxisome Proliferator Activated Receptors (PPAR). PPARs have an anti-proliferative effect as well as the ability to reduce tumour expression, especially in lung cancer lines.

• PPARs degrade amyloid-beta plaque – Alzheimers and Parkinsons

• PPAR regulates genes involved in energy homeostasis, lipid uptake and insulin sensitivity

• CBD acts as an allosteric receptor modulator meaning it can enhance or inhibit how a receptor responds

• CBD reduces anxiety by changing the shape of the GABA receptors leading to a heightened calming effect

• CBD also weakens THC’s affinity for CB1 receptors reducing the psycho active effect


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