The entourage effect refers to a phenomenon where different compounds in cannabis, such as cannabinoids, terpenes, and flavonoids, work synergistically to enhance the therapeutic effects of each other. This concept suggests that the medicinal benefits of the whole plant are greater than the sum of its parts when these compounds are used together, rather than in isolation.
The most commonly discussed components of the entourage effect include:
- Cannabinoids: These are chemical compounds found in cannabis, with THC (tetrahydrocannabinol) and CBD (cannabidiol) being the most well-known. THC is primarily responsible for the psychoactive effects, while CBD is associated with many therapeutic benefits without causing a high.
- Terpenes: These are aromatic compounds that give cannabis strains their distinct smell and flavour, such as limonene (citrusy scent) and myrcene (earthy and musky). Terpenes are believed to play a role in modifying the effects of cannabinoids.
- Flavonoids: These are plant compounds that also contribute to the flavour, colour, and aroma of cannabis and may have anti-inflammatory and antioxidant properties.
Research into the entourage effect is ongoing, but it highlights the importance of the interactions between these various components when considering the medical and therapeutic use of cannabis. This concept is used to explain why some people prefer full-spectrum cannabis extracts, which contain a range of cannabinoids and terpenes, over isolated compounds like pure CBD or THC.
